alleviation of experimental allergic encephalomyelitis in c57bl/6 mice by soy daidzein.

Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein.

Experimental allergic encephalomyelitis (EAE) is considered as the murine model of multiple sclerosis. Daidzein a phytostrogenic compound of soy is known to impose immunomodulatory and antioxidative effects. We conducted this study to assess the potential protective and therapeutic effects of daidzein on allergic encephalomyelitis.C57BL/6 mice were induced with allergic encephalomyelitis using ...

Inhibition of acute experimental allergic encephalomyelitis in mice by colchicine

Colchicine was found to inhibit the clinical and histopathological manifestations of monophasic experimental allergic encephalomyelitis in mice. For inhibition of actively induced disease, inoculation of colchicine at the time of encephalitogenic challenge was found to be most effective. In adoptive transfer experiments, lymph node cells (LNC) from colchicine treated donors failed to transfer t...

Brief Definitive Report INHIBITION OF ACUTE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN MICE BY COLCHICINE

Experimental allergic encephalomyelitis (EAE) is widely regarded as a laboratory analog of multiple sclerosis (MS) . Recent evidence both in MS and EAE point to the fact that activated macrophages appear to be proximal agents of myelin destruction (1) . In view of these findings and encouraged by the preliminary results of a trial of colchicine in MS patients, we asked the question whether or n...

Metabolomics approaches in experimental allergic encephalomyelitis.

A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment. The aims of this study were thus to find significant metabolic biomarkers of inflammation and identify the site of inflammation in the central nervous system (CNS) during the acute signs in of the disease using metabolomics. All the EAE...

Experimental Allergic Encephalomyelitis in Oxygen Immunosuppression : Modification

Myelin-binding antibodies in experimental "allergic" encephalomyelitis.

Antibodies with a specificity for myelin, as demonstrated by immunofluorescence, are present in the sera of rabbits injected with spinal cord. These antibodies react with both adult rabbit and human spinal cord but not with unmyelinated areas of neonatal human spinal cord.